Protein Details: Gamma-aminobutyric acid receptor subunit alpha-3
Protein ID
ICDB_Pro_0394
Protein Name
Gamma-aminobutyric acid receptor subunit alpha-3
Gene Name
Gabra3; Gabra-3
Organism
Rattus norvegicus (Rat)
Length
493 amino acids
AlphaFoldDB
AF-P20236-F1-model_v4.pdb
Function
Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA); a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels; also named GABA(A) receptors (GABAAR); consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA; GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential; thereby reducing nerve transmission (By similarity).
Sequence
Ligand Binding
Binding Site
BINDING 119; /ligand="4-aminobutanoate": "ligand shared with the neighboring beta subunit"; BINDING 182; /ligand="4-aminobutanoate": "ligand shared with the neighboring beta subunit"
Disease
Location
Expressed in most brain regions. Expressed in lungs; in alveolar epithelium (PubMed:17003036).
DOI ID
10.1016/0014-5793(90)80118-3; 10.1101/sqb.1990.055.01.006; 10.1038/nature02426; 10.1074/jbc.m606895200; 10.1038/ncomms1871; 10.1021/pr400783j
RefSeq
NP_058765.3; XP_017457405.1